印遇龙;杨哲;

• 1:湖南农业大学动物科技学院
• 2:中国科学院亚热带农业生态研究所

摘要(Abstract)：

饲用促生长抗生素(以下简称"抗生素")滥用引发的耐药性和生态破坏问题终将威胁人类健康,天然植物因其安全有效易得的优势成为了替代抗生素研究与应用的热点。文章综述了国内外近期的抗生素替代物评价方法体系,并阐述天然植物在直接抑菌作用和增强免疫机能的双重作用机制。天然植物中的多酚类、精油类、多糖类等活性成分是替抗的物质基础。从多数试验结果来看,植物提取物能够在替抗的前提下,对畜禽的生长性能、抗氧化能力、肠道形态、菌群结构或免疫功能有所改善。文章还讨论了天然植物替抗研究应用存在的一些问题,旨在为未来发展方向提供建设性意见。

关键词(KeyWords)： 天然植物;促生长抗生素;植物提取物;中草药;抗生素替代品

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 印遇龙;杨哲;

Email:

DOI: 10.13302/j.cnki.fi.2020.24.001

参考文献(References)：

• [1]Jukes T H,Stok stad E L R,Tayloe R R,et al.Growth-promoting Effect of Aureomycin on Pigs[J].Arch.Biochem.,1950,26(2):324-325.
• [2]王云鹏,马越.养殖业抗生素的使用及其潜在危害[J].中国抗生素杂志,2008,33(9):519-523.
• [3]Zhu Y G,Johnson T A,Su J Q,et al.Diverse and Abundant Antibiotic Resistance Genes in Chinese Swine Farms[J].Proceedings of the National Academy of Sciences of the United States of America,2013,110(9):3435-3440.
• [4]Zhang L,Gu J,Wang X,et al.Fate of Antibiotic Resistance Genes and Mobile Genetic Elements During Anaerobic Co-digestion of Chinese Medicinal Herbal Residues and Swine Manure[J].Bioresource Technology,2018,250:799-805.
• [5]印遇龙.中国生猪产业与饲料行业发展建议[J].中国科学院院刊,2018(12):1337-1341.
• [6]Pietro C,Viviane V,Estefania P C,et al.Biomarkers of Gastrointestinal Functionality in Animal Nutrition and Health[J].Animal Feed Science and Technology,2019,250(S1):9-31.
• [7]He L,Li H,Huang N,et al.Alpha-ketoglutarate Suppresses the Nf-κb-mediated Inflammatory Pathway and Enhances the Pxrregulated Detoxification Pathway[J].Oncotarget,2017,8(61):102974-102988.
• [8]Olayanju A,Jones L,Greco K,et al.Application of Porcine Gastrointestinal Organoid Units as a Potential in Vitro Tool for Drug Discovery and Development[J].Journal of Applied Toxicology,2019,39(1):4-15.
• [9]Yin Y,Guo S,Wan D,et al.Enteroids:Promising in Vitro Models for Studies of Intestinal Physiology and Nutrition in Farm Animals[J].Journal of Agricultural&Food Chemistry,2019,67(9):2421-2428.
• [10]刘华,刘秀斌,吴俊,等.饲用植物及其提取物在饲料替抗中的应用[J].饲料工业,2020,41(12):20-24.
• [11]Mann J.Antibiotics:Actions,Origins,Resistance[M].Asm Press,2003.
• [12]David a.rasko Vanessa-Sperandio.Anti-virulence strategies to combat bacteria-mediated disease[J].Nature Reviews Drug Discovery,2010,9(2):117-128.
• [13]Mulat M,Pandita A,Khan F.Medicinal Plant Compounds for Combating the Multi-drug Resistant Pathogenic Bacteria:a Review[J].Current Pharmaceutical Biotechnology,2019,20(3):183-196.
• [14]Gong J,Yin F,Hou Y,et al.Review:Chinese Herbs as Alternatives to Antibiotics in Feed for Swine and Poultry Production:Potential and Challenges in Application[J].Canadian Journal of Animal Science,2014,94(2):223-241.
• [15]Xu Z,Zhao Y,Hu Y,et al.Gut Microbiota-targeted,Wholebody Systems Biology for Understanding Traditional Chinese Medicine[J].World Science&Technology,2011,13(2):202-212.
• [16]Nicholson K J.Global Systems Biology,Personalized Medicine and Molecular Epidemiology[J].Molecular Systems Biology,2006,2(1):52.
• [17]Blander J M,Longman R S,Iliev I D,et al.Regulation of Inflammation By Microbiota Interactions with the Host[J].Nature Immunology,2017,18(8):851-860.
• [18]R.Wa,S.Aai,Ling Z,et al.Dietary Phytonutrients and Animal Health:Regulation of Immune Function During Gastrointestinal Infections[J].Journal of Animal Science,2020,98(4):1-32.
• [19]Ahn-jarvis J,Parihar,Doseff A.Dietary Flavonoids for Immunoregulation and Cancer:Food Design for Targeting Disease[J].Antioxidants,2019,8(7):202-233.
• [20]费鹏,赵胜娟,陈曦,等.植物多酚抑菌活性、作用机理及应用研究进展[J].食品与机械,2019,35(7):226-230.
• [21]Javier alvarez-martinez F,Barrajon-catalan E,Antonio encinar J,et al.Antimicrobial Capacity of Plant Polyphenols Against Gram-positive Bacteria:a Comprehensive Review[J].Current Medicinal Chemistry,2020,27(15):2576-2606.
• [22]Nakayama M,Shimatani K,Ozawa T,et al.Mechanism for the Antibacterial Action of Epigallocatechin Gallate (egcg) on Bacillus Subtilis[J].Bioscience Biotechnology and Biochemistry,2015,79(5):845-854.
• [23]Kusuda M,Inada K,Ogawa T O,et al.Polyphenolic Constituent Structures of Zanthoxylum Piperitum Fruit and the Antibacterial Effects of Its Polymeric Procyanidin on Methicillin-resistant Staphylococcus Aureus[J].Bioscience Biotechnology&Biochemistry,2006,70(6):1423-1431.
• [24]白乌日汗,孙海洲.植物精油在动物营养中的研究进展[J].畜牧与饲料科学,2009,30(3):47-48.
• [25]Chen Y,Zhang H,Wang Y,et al.Sulfated Modification of the Polysaccharides From Ganoderma Atrum and Their Antioxidant and Immunomodulating Activities[J].Food Chemistry,2015,186:231-238.
• [26]吴香云,刘亚娜,周喆麒,等.多糖类化合物的抗菌作用及其机制研究进展[J].畜牧兽医学报,2020,51(6):1167-1176.
• [27]Naveed M,Hejazi V,Abbas M,et al.Chlorogenic Acid (cga):a Pharmacological Review and Call for Further Research[J].Biomedecine&Pharmacotherapie,2017,97:67-74.
• [28]张少航,巫攀,王启军,等.兽用博落回散对常用益生菌生长的影响[J].饲料工业,2018,39(16):40-44.
• [29]Ding H,Cao A,Li H,et al.Effects of Eucommia Ulmoides Leaf Extracts on Growth Performance,Antioxidant Capacity and Intestinal Function in Weaned Piglets[J].Journal of Animal Physiology and Animal Nutrition,2020,104(4):1169-1177.
• [30]Kong X F,Yin F G,He Q H,et al.Acanthopanax Senticosus Extract as a Dietary Additive Enhances the Apparent Ileal Digestibility of Amino Acids in Weaned Piglets[J].Livestock Ence,2009,123(2):261-267.
• [31]Cui Y,Tian Z,Wang G,et al.Citrus Extract Improves the Absorption and Utilization of Nitrogen and Gut Health of Piglets[J].Animals,2020,10(1):112-123.
• [32]Jimenez M J,Berrios R,Stelzhammer S,et al.Ingestion of Organic Acids and Cinnamaldehyde Improves Tissue Homeostasis of Piglets Exposed to Enterotoxic Escherichia Coli (etec)[J].Journal of Animal Science,2020,98(2).
• [33]Guo S,Ma J,Xing Y,et al.Artemisia Annua L.Aqueous Extract as an Alternative to Antibiotics Improving Growth Performance and Antioxidant Function in Broilers[J].Italian Journal of Animal Science,2020,19(1):399-409.
• [34]柴毛毛,郭玉光,李阳源,等.博落回提取物替代抗生素对肉鸡生长性能、盲肠微生物及盲肠紧密连接的影响[J].微生物学报,2020,60(8):1718-1728.
• [35]Okti H,Tri U,Marla A,et al.Effect of Mangosteen (Garcinia Mangostana L.) Peel Extract as an Antibiotic Growth Promoter on Growth Performance and Antibiotic Resistance in Broilers[J].Veterinary World,2019,13(4):796-800.
• [36]Ragan V E.The Animal and Plant Health Inspection Service(aphis) Brucellosis Eradication Program in the United States[J].Veterinary Microbiology,2002,90(4):8-11.
• [37]柏妍,郎侠,王彩莲,等.饲粮中添加牛至精油和莫能菌素对荷斯坦犊牛血清生化指标、消化酶活性及瘤胃微生物区系的影响[J].畜牧兽医学报,2019,50(12):2458-2469.
• [38]田志梅,崔艺燕,杜宗亮,等.抗生素替代物在畜禽养殖中的研究及应用进展[J].动物营养学报,2020,32(4):1516-1525.
• [39]杨建武,曾建国,杨哲.开发饲用植物相关问题的探讨[J].饲料广角,2015,464(17):28-30.
• [40]郭盛,段金廒,赵明,等.基于药材生产与深加工过程非药用部位及副产物开发替代抗生素饲用产品的可行性分析与研究实践[J].中草药,2020,51(11):2857-2862.
• [41]冯智茂,袁勇,张云飞,等.中草药药渣在动物生产中的应用[J].饲料工业,2020,41(10):16-18.
• [42]刘凤华,许剑琴.天然植物饲料原料团体标准落地迫在眉睫[J].中国畜牧业,2020(8):28-29.
• [43]Oh S Y,Yun W,Lee J H,et al.Effects of Essential Oil (blended and Single Essential Oils) on Anti-biofilm Formation of Salmonella and Escherichia Coli[J].Journal of Animal Science and Technology,2017,59(1):1-5.